Semaglutide Weight Loss Guide: Complete Dosing Protocol for 2026 Semaglutide has become the most prescribed GLP-1 receptor agonist for weight management in 2026. This guide covers everything you need to know about proper dosing, what to expect at each stage, and how to maximize your results. Starting Protocol (Week 1-4) Begin with 0.25mg weekly subcutaneous injection. This low starting dose helps your body adjust to the medication and minimizes side effects like nausea. Most patients experience appetite reduction within the first 1-2 weeks. Dose Escalation (Month 2-6) Gradually increase to 0.5mg at week 5, then 1.0mg at week 9. Your healthcare provider may adjust the schedule based on your tolerance. Average weight loss during this period: 5-10% of body weight. Maintenance Phase (Month 6-12) Full therapeutic dose of 1.7mg or 2.4mg weekly. STEP clinical trials showed 15-17% average body weight loss at this stage. Continue monitoring metabolic markers including blood sugar, cholesterol, and blood pressure. Learn More For detailed week-by-week dosing charts, side effect management strategies, and product sourcing information, visit the complete semaglutide dosing guide at Glunova Biotech. Quality semaglutide products with full Certificate of Analysis documentation are available at glunovabio.com.